Excellent Hydroxypropyl Cellulose with High Quality

• CAS No.: 9004-64-2
• Color: White
• Appearance: Powder
• Transport Package: Paper
• Specification: large
• Trademark: china
• Origin: China
• HS Code: 2801100000
• Production Capacity: 5000kg/Year

Product Description

Spheroids in the macroporous HA Gal sponge must be retrieved for further characterization. Development of a degradable/cleavable sponge is needed to recover the spheroids more easily. Drug adsorption on the HA Gal sponge has been observed and a thorough investigation on the mechanism and kinetics of drug adsorption is in progress. Decreasing the sponge size in smaller well plates can partially remedy the problem, i.e., 96-well and 384-well sponges can have less serious drug absorption than 48- or 24-well size sponge. Surface modification of the sponge may be required to minimize drug adsorption when using the sponge to form spheroids for drug testing. For membrane-constrained spheroids, the surface treatment is less critical in reducing drug absorption, especially for ultrathin porous membrane. The surface treatment is more important for controlling the cell-substrate interaction and maintaining spheroid size and cellular functions. Another issue one needs to be careful is the fragility of the ultrathin porous membrane. Even though Parylene C is much less brittle than silicon nitride (Si₃N₄) membrane that we have developed previously (Zhang et al., 2008), and we have reinforced its mechanical stability by building thicker frames into the Parylene C membrane, one still needs to handle it carefully.