| CAS No.: | 5026-62-0 |
|---|---|
| Color: | White |
| Appearance: | Powder |
| Transport Package: | Paper |
| Specification: | large |
| Trademark: | china |
| Samples: |
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Audited Supplier Methylparaben has been used as a preservative used in the food, cosmetic, and pharmaceutical industries for over 50 years. The chemical formula for methylparaben sodium is C8H7NaO3. It may also found naturally in fruits like blueberries where it has antimicrobial activity. Methylparaben sodium is the sodium salt form of methylparaben.
Methylparaben is completely absorbed through the skin or after ingestion, and it is hydrolyzed to para-hydroxybenzoic acid, and metabolites are rapidly excreted in the urine. There is no evidence of accumulation. It is on the FDA generally regarded as safe list.
Acute toxicity studies in animals indicate that methylparaben is practically non-toxic by both oral and injectable routes. It has not been shown to be teratogenic, carcinogenic, mutagenic or embryotoxic.
It does not appear to be irritating when used topically, although some people may show cross-sensitivity in people allergic to local anesthetics that are metabolized to para-aminobenzoic acid. Cases of local contact dermatitis have been reported.[1][2][3] All parabens have similar structure to estrogen. Studies conducted in the early 2000s located traces of parabens in breast tumors, but evidence has not linked parabens with breast cancer.
The Cosmetic Ingredient Review (CIR) reviewed the safety of methylparaben, propylparaben, and butylparaben in 1984 and concluded they were safe for use in cosmetic products at levels up to 25%. Typically parabens are used at levels ranging from 0.01 to 0.3%.[4]
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