Enzymatic Hydrolysis of Glycyrrhizin with High Quality

• CAS No.: 578-86-9
• Color: Brown
• Appearance: Powder
• Transport Package: Paper
• Specification: large
• Trademark: china
• Origin: China
• HS Code: 2801100000
• Production Capacity: 5000kg/Year

Product Description

Objective Liposome surface modified with glycyrrhizin can enhance liver targeting of the drug carrier.Therefore,we try to construct the liposome which surface was inlaid with glycyrrhizic acid by enzyme-catalyzed cou-pled reaction.Methods With glycyrrhizin and vinyl stearate as substrates as reaction medium and immobi-lized-lipase Novozym 435 as catalyst,we investigated effects of factors of the enzyme concentration,molar ratio of substrates,reaction temperature and reaction time on the reaction rate of glycyrrhizin.Results Under the condition of enzyme concentration at 40 mg.mL-1,the molar ratio of glycyrrhizic acid to vinyl stearate being 1 ∶ 5,and react-ing at 60 ºC for 48 h,the reaction rate of glycyrrhizin was up more than 60 %.Conclusion Enzymatic synthesis of liposome surface modified with glycyrrhizin is simple and feasible,which has potential prospective application.Objective Liposome surface modified with glycyrrhizin can enhance liver targeting of the drug carrier.Therefore,we try to construct the liposome which surface was inlaid with glycyrrhizic acid by enzyme-catalyzed cou-pled reaction.Methods With glycyrrhizin and vinyl stearate as substrates, reaction medium and immobi-lized-lipase Novozym 435 as catalyst,we investigated effects of factors of the enzyme concentration,molar ratio of substrates,reaction temperature and reaction time on the reaction rate of glycyrrhizin.Results Under the condition of enzyme concentration at 40 mg.mL-1,the molar ratio of glycyrrhizic acid to vinyl stearate being 1 ∶ 5,and react-ing at 60 ºC for 48 h,the reaction rate of glycyrrhizin was up more than 60 %.Conclusion Enzymatic synthesis of liposome surface modified with glycyrrhizin is simple and feasible,which has potential prospective application.