CITREM (and related organic acid esters of mono- and diglycerides) was evaluated at its ninth (1966), tenth (1967) and seventeenth (1973) meetings (JECFA, 1966, JECFA, 1967, JECFA, 1974). An acceptable daily intake (ADI) "not specified" was allocated for CITREM (and related organic acid esters) at the seventeenth meeting. Specifications for CITREM were prepared at the 35th meeting (1989), published in FNP 49 (1990) and FNP 52 (1992). Specifications for metallic contaminants and were revised at the 61st JECFA (2003), 79th JECFA (2014), 82nd JECFA (2016) and 86th JECFA (2018) where the specifications were made tentative, requiring a replacement validated method for the obsolete packed column gas chromatographic method for the determination of total citric acid in its specifications monograph. A new package of information was received on new validated methods for the determination of total glycerol and total citric acid. Therefore, CITREM was included in the agenda of the 87th JECFA (2019), new specifications were prepared, and the tentative status was removed.
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