Folic Acid

• CAS No.: 59-30-3
• Color: White
• Appearance: Powder
• Transport Package: Paper
• Specification: large
• Trademark: china
• Model NO.: E1422
• Origin: China
• HS Code: 2930400000
• Production Capacity: 5000kg/Year

Product Description

1.1 Name
Folinic acid
1.2 Synonyms

(6R,S)-5-Formyltetrahydrofolate2-[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]aminopentanedioic acid5-formyl-5,6,7,8-tetrahydrofolate5-Formyl-5,6,7,8-tetrahydrofolic acid5-formyl-5,6,7,8-tetrahydropteroyl-l-glutamicacid5-formyltetrahydrofolate5-formyltetrahydrofolic acid5-Formyltetrahydropteroylglutamic acidCFFolinic acid-SFGlutamic acid, N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, L-KunyrinLeucalleucoverinLeucovorinL-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-Glutamic acid, N-[4-[[(2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-l-LeucovorinN-[4-[[(2-Amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acidN5-formyl-5,6,7,8-tetrahydrofolateN5-Formyl-5,6,7,8-tetrahydrofolic acidN5-formyl-tetrahydrofolateN5-Formyltetrahydrofolic acidN5-Formyl-THFWelcovorin

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1.3 CAS No.
58-05-9

1.4 CID
135403648

1.5 EINECS(EC#)
200-361-6

1.6 Molecular Formula
C20H23N7O7 (isomer)

1.7 Inchi
InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12?,13-/m0/s1

1.8 InChIkey
VVIAGPKUTFNRDU-ABLWVSNPSA-N

1.9 Canonical Smiles
C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O

1.10 Isomers Smiles
C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O

2. Properties

2.1 Density
1.4485 (rough estimate)

2.1 Melting point
245°C (rough estimate)

2.1 Boiling point
573.92°C (rough estimate)

2.1 Refractive index
1.6800 (estimate)

2.1 Flash Point
°C

2.1 Precise Quality
473.16600

2.1 PSA
215.55

2.1 logP
1.15290

2.1 Solubility
>1350g/L(25 ºC)

2.2 Appearance
Crystals from water with 3 mol of water of crystallization.

2.3 Chemical Properties
Crystals. Sparingly soluble in water.

2.4 Color/Form
Crystals from water with 3 mol of water of crystallization.

2.5 pKa
3.1, 4.8, 10.4(at 25ºC)

2.6 Water Solubility
>1350g/L(25 ºC)

2.7 Spectral Properties
Specific optical rotation: +16.76 deg at 25 deg C/D (5% sodium carbonate, concentration = 3.5%).
UV: 1-870 (Philip et al., Organic Electronic Spectral Data, John Wiley & Sons, New York)

2.8 StorageTemp
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

3. Use and Manufacturing

3.1 Definition
ChEBI: A formyltetrahydrofolic acid in which the formyl group is located at position 5.

3.2 Usage
Anti-anemic (folate deficiency); antidote (to folic acidantagonists).

4. Safety and Handling

4.1 Exposure Standards and Regulations
The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed prescription drug products, incl leucovorin calcium, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act. /Leucovorin Calcium/

4.2 Octanol/Water Partition Coefficient
log Kow = -4.45 /Estimated/

4.3 DisposalMethods
SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

4.4 Formulations/Preparations
Tablets, 5, 10, 15, and 25 mg. Powder for oral solution, 1 mg, following reconstitution. Ampules, 3 mg/ml and 5 mg/ml. Vials, 50, 100, and 350 mg. /Leucovorin calcium/
Oral Tablets, 5 mg (of leucovorin), Wellcovorin (with povidone; scored), Burroughs Wellcome; 10 mg (of leucovorin), Leucovorin Calcium Tablets (scored), Lederle; 15 mg (of leucovorin), Leucovorin Calcium Tablets (scored), Lederle; 25 mg (of leucovorin), Wellcovorin (with povidone; scored), Burroughs Wellcome; Parenteral For Injection, 50 mg (of leucovorin), Leucovorin Calcium for Injection, Cetus, Elkins-Sinn, Lederle; 100 mg (of leucovorin), Leucovorin Calcium for Injection, Cetus, Lederle; Wellcovorin, Burroughs Wellcome; 350 mg (of leucovorin), Leucovorin Calcium for Injection, Lederle; Injection, 3 mg (of leucovorin) per ml, Leucovorin Calcium Injection (with benzyl alcohol 0.9%), Lederle. /Leucovorin calcium/

5. MSDS

 

2.Hazard identification

2.1 Classification of the substance or mixture

no data available

2.2 GHS label elements, including precautionary statements

Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Precautionary statement(s)
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available