Product name: Calcium pantothenate
Scientific name: Calcium pantothenate
CAS number: : 137-08-6
Nicknames: calcium d-pantothenate,medicinal; d-pantothenate calcium; Calcium panthothenate; Pantothenic Acid Calcium Salt; D-(+)-pantothenic acid calcium salt; calcium bis{3-[(2,4-dihydroxy-3,3-dimethylbutanoyl)amino]propanoate}; calcium bis(3-{[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino}propanoate); calcium 3-[[(2S)-2,4-dihydroxy-3,3-dimethyl-butanoyl]amino]propanoate; Calcium D-Pantothenate; Vitamin B5; D-(+)-Pantothenic Acid Calcium Salt
Molecular formula: C18H32N2O10Ca
Molecular weight: : 476.5321
Purity: : HPLC≥98%
Brand: : pureonebio
Specification: : 20mg
Details: : Calcium pantothenate is the standard product (reference product) provided by pure excellent biology, the English name of the product is. Calcium pantothenate, CAS No. 137-08-6, is of stable purity and rich product specification. It is specially used for research and analysis.
Compound profile
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Basic information
Chemical formula: C18H32CaN2O10
Molecular weight: 476.532
CAS number: 137-08-6
EINECS number: 205-278-9
Physical and chemical properties
Density: 1.266g/cm3
Melting point: 190°C
Boiling point: 551.5ºC
Flash point: 145 °C
Appearance: white crystalline powder
Solubility: Soluble in glycerol, slightly soluble in ethanol and
Computational chemical data
Reference value for calculating hydrophobic parameter (XlogP) : None
Number of hydrogen bond donors: 6
Number of hydrogen bond receptors: 10
Number of rotatable bonds: 10
Number of tautomers: 3
Topological molecular polar surface area (TPSA) : 219
Number of heavy atoms: 31
Surface charge: 0
Complexity: 233
Number of isotope atoms: 0
Determine the number of protonic centers: 2
Number of uncertain protonic centers: 0
Determine the number of chemical bond stereocenter: 0
Number of uncertain bond stereocentes: 0
Number of covalent bond units: 3 [1]
use
Mainly used in medicine, food and feed additives. It is A component of coenzyme A, involved in the metabolism of carbohydrates, fats and proteins, and is an indispensable trace substance for human and animal to maintain normal physiological functions. More than 70% are used as feed additives.
It is clinically used to treat vitamin B deficiency, peripheral neuritis, and colic after surgery. Involved in the metabolism of protein, fat and sugar in the body.
Drug introduction
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In vivo process
The oral amount of calcium pantothenate is absorbed from the gastrointestinal tract and is widely distributed and not metabolized in the body. 70% of the original drug is excreted in the urine and 30% in the stool.
Pharmacological action
Calcium pantothenate is a vitamin b group substance, which is a component of coenzyme A in a variety of metabolic links, including carbohydrates, proteins, fats and essential for the normal maintenance of epithelial function.
indication
Mainly used clinically for the prevention and treatment of calcium pantothenate deficiency (such as malabsorption syndrome, tropical oral inflammatory diarrhea, coeliac disease, localized enteritis, or the application of calcium pantothenate antagonists), the adjuvant treatment of vitamin B deficiency, and the adjuvant treatment of some other diseases (such as poisoning, postoperative intestinal obstruction, rheumatoid disease, etc.). It is also used for vitamin B deficiency and peripheral neuritis, and colic after surgery.
Dosage and usage
Oral: 10 to 20mg each time, 3 times a day. Postoperative colic: intramuscular injection of 50mg each time, 3 times a day.
Pharmacopoeia information
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Basic information
This product is (R)-N-(3, 3-dimethyl-2, 4-dihydroxy-1-oxy-butyl) -3-alanine calcium salt, according to the calculation of dry products, calcium (Ca) should be 8.20%~8.60%, nitrogen (N) should be 5.70%~6.00%.
character
This product is white powder, odorless, moisture-inducing, aqueous solution is neutral or weakly alkaline.
This product is soluble in water, very slightly soluble in ethanol, and almost insoluble in or ether.
Specific rotation
Take this product, weigh it accurately, dissolve it with water and dilute it quantitatively to make a solution containing about 50mg in every 1mL, measured according to law (general rule 0621), and the specific curl is +25° to +28.5°.
identify
1. Take about 50mg of this product, add 5mL of test solution, shake, add 2 drops of copper sulfate test solution, that is, blue purple.
2, take about 50mg of this product, add 5mL of test solution, shake, boil for 1 minute, cool, add 1 drop of phenolphthalide indicator solution, add solution (9→100), add 0.5mL more after the solution fades, add 2 drops of test solution, that is, bright yellow.
3, the infrared light absorption pattern of this product should be consistent with the control pattern (spectrum set 208 figure).
4, this product shows the identification reaction of calcium salt (general rule 0301).
Inspect
Ph (pH)
Take 1.0g of this product, add 20mL of water and dissolve it, determine according to law (general rule 0631), and the pH value should be 6.8~8.0.
Clarity and color of the solution
The solution under pH should be clear and colorless.
Beta-alanine
According to thin layer chromatography (General rule 0502) test.
Test product solution: Appropriate amount of this product, precision weighing, adding water to dissolve and quantitative dilution to make a solution containing about 40mg per 1mL.
Reference product solution: Take an appropriate amount of β-alanine reference product, weigh it accurately, dissolve it with water and quantitatively dilute it to make a solution containing about 0.4mg per 1mL.
Chromatographic conditions: Silica gel G thin layer plate was used, and ethanol-water (65:35) was used as development agent.
Determination method: Absorb 5µL of test product solution and control product solution, respectively, on the same thin layer plate, spread, dry, spray with ninhydrin test solution, dry at 110ºC for 10 minutes, immediately check.
Limit: If the test product solution shows impurity spots corresponding to the main spots of the control product solution, its color should not be deeper than the main spots of the control product solution (1.0%).
Drying loss
Take this product, dry at 105°C to constant weight, weight loss must not exceed 5.0% (general rule 0831).
Heavy metal
Take 1.0g of this product, add an appropriate amount of water to dissolve, add 1.0mL of solution (9→100), add water to dilute to 25mL, check according to law (the first method of general rules 0821), containing heavy metals shall not exceed 20 parts per million.
Content determination
calcium
Take about 0.5g of this product, weigh it accurately, dissolve it with 100mL of water, add 15mL of test solution and 0.1g of calpurpurin indicator, and titrate with 0.05mol/L of disodium tetraacetate titration solution until the solution changes from purple red to pure blue. Each 1mL of sodium tetraacetate titrant (0.05mol/L) is equivalent to 2.004mg of calcium (Ca).
nitrogen
Take about 0.5g of this product, precision weighing, according to nitrogen determination method (general rule 0704 first method) determination. Each 1mL of sulfuric acid titrant (0.05mol/L) is equivalent to 1.401mg of nitrogen (N).
category
Vitamins.
Lay by
Seal and store in a dry place.
preparation
Calcium pantothenate tablets. [2]
Safety information
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Security terminology
S24/25: Avoid contact with skin and eyes.
Avoid skin and eye contact.
Risk terminology
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Harmful by inhalation, in contact with skin and if swallowed.
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