| CAS No.: | 137-66-6 |
|---|---|
| Color: | White |
| Appearance: | Powder |
| Transport Package: | Paper |
| Specification: | large |
| Trademark: | china |
| Samples: |
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Audited Supplier Ascorbyl palmitate is a highly bioavailable, fat-soluble form of ascorbic acid (vitamin C) and possesses all the properties of native water-soluble counterpart, that is vitamin C. It is a potent antioxidant in protecting lipids from peroxidation and is a free radical scavenger.
To enhance its chemical stability, ascorbyl palmitate was processed as a nanosuspension using an HPH (20 cycles at 1500 bar) technique using sodium dodecyl sulfate and polysorbate 80 as a stabilizer. Tween 80 was comparatively effective in producing uniform nanosuspensions (mean particle size of 365 nm) with improved active pharmaceutical ingredient (API) chemical stability. Further enhancement in drug stability can be achieved by lyophilization. Authors confirmed the stability of trehalose incorporated ascorbyl palmitate nanosuspensions (Teeranachaideekul et al., 2008). Recently, a combination technique (milling followed by HPH) is applied to produce smaller nanocrystals of ascorbyl palmitate using sugar-based nonionic surfactant decyl glucoside. Two different milling bead sizes were employed, namely 0.4-0.6 and 0.2 mm. The nanocrystals produced using larger bead dispersion of mean particle size of 442 nm and small bead size produced a dispersion of 286 nm. Further reduction in mean particle size down to 354 nm is observed only for the dispersions produced using larger beads after one cycle at 500 bar and 286 nm after one cycle at 1500 bar. The increased saturation solubility of ascorbyl palmitate can exhibit higher concentration gradient profile and faster dissolution of smaller crystals (Romero et al., 2013).
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